Shopping Cart

Remove All

Your shopping cart is currently empty

SN 2

Select Batch

Purity:99.20%

Resource Download

COA LCMS HNMR

SN 2

Catalog No. T12941Cas No. 823218-99-1

SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$44	In Stock
5 mg	$73	In Stock
10 mg	$119	In Stock
25 mg	$253	In Stock
50 mg	$495	In Stock
100 mg	$729	In Stock
500 mg	$1,490	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "SN 2"

Product Introduction

Bioactivity

Description

SN 2 is a novel and potent TRPML3 ion channel activator(EC50 of 1.8±0.13 μM).

In vitro

When activated with 10 μM SN-2, at -80 mV, the conductance of the TRPML3 channel is approximately 10 pS. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone.SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at 80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K).

Chemical Properties

Molecular Weight	255.35
Formula	C17H21NO
Cas No.	823218-99-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (65.27 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9162 mL	19.5810 mL	39.1619 mL	195.8097 mL
5 mM	0.7832 mL	3.9162 mL	7.8324 mL	39.1619 mL
10 mM	0.3916 mL	1.9581 mL	3.9162 mL	19.5810 mL
20 mM	0.1958 mL	0.9790 mL	1.9581 mL	9.7905 mL
50 mM	0.0783 mL	0.3916 mL	0.7832 mL	3.9162 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc